Synthesis and Inhibition of Influenza H1N1 Virus by Indolo-Glycyrrhetic Acid Cyanoesters by Anastasiya V. Petrova Svetlana V. Belyaevskaya & Vladimir V. Zarubaev
Author:Anastasiya V. Petrova, Svetlana V. Belyaevskaya & Vladimir V. Zarubaev
Format: pdf
Tags: Two new indolo-glycyrrhetic acid derivatives containing cyano-substitutent at C30 have been synthesized, and their anti-influenza activity has been evaluated in vitro. The resulting data demonstrated moderate inhibitory activity against the H1N1 virus with IC50 29 and 23 M, respectively. The value of SI 18 and 21 confirm low toxicity and potential of new compounds for following research and development of new biological agents., 18-glycyrrhetinic acid; cyano-derivatives; antiviral activity; anti-influenza; H1N1
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